Matthew Jenior

Summary

I am a highly motivated bench-turned-informatics scientist with an extremely strong background in not only the biology of microbial ecosystems, but the computational means to study them at a fine resolution. I have independently moved large projects from the genesis of original ideas, all the way to presentation and publication of finished work during my PhD. thesis. Accomplishing these goals involved developing novel workflows to harness large metagenomic and metatranscriptomic datasets for understanding complex community-level interactions that drive human health and disease. Additionally, having experience with research both in academic and industry settings, I am uniquely suited to collaborate with a variety of personnel to complete projects on time using innovative approaches.

Research & Experience

Postdoctoral Research Associate with Dr. Jason Papin, University of Virginia, August 2017 - present

  • My postdoctoral research centers on implementing metabolic modeling techniques at the metagenome-scale with integration of high-throughput metatranscriptomic and metabolomic data in order to engineer optimal probiotic cocktails against multiple diseases of the GI tract based on combined metabolic signatures.

Ph.D. Candidate with Dr. Patrick Schloss, University of Michigan, April 2012 – July 2017

  • My dissertation research investigated the role of nutrient niche exclusion by the gut microbiome in colonization resistance to Clostridium difficile infection. I accomplished this through the use of metagenomic-enabled metatranscriptomics to identify how community-level metabolism shifted in response to antibiotic treatment and pathogen colonization.

Research Internship, Janssen Pharmaceuticals, June 2011 – August 2011

  • Immunological Research Department – Used machine learning algorithms to predict Crohn’s disease patient response to drug therapy combining both microbiome and host epithelial microarray data.

Research Internship, Kent State University, June 2010 – August 2010

  • Laboratory of Dr. Helen Piontkivska – Constructed a relational database of HIV-1 epitope co-occurrence and immunodominance across subtypes of the virus to uncover frequently occurring patterns for potential vaccine design.

Research Assistantship, Hiram College, February 2009 – December 2010

  • Laboratory of Dr. Bradley Goodner – Worked to elucidate functional differences between five putative copies of glutamine synthetase in Agrobacterium tumefaciens using forward genetic screens.

Highlighted Skills

Education

  • Ph.D. – Microbiology & Immunology, University of Michigan, July 2011 - July 2017
  • B.A. – Biology, Hiram College, August 2007 – May 2011

Publications

Jenior ML, Leslie JL, Young VB, & Schloss PD. (2018). Clostridium difficile differentially alters the structure and metabolism of distinct cecal microbiomes to promote persistent colonization during infection. mSphere. 3 (3) e00261-18; DOI: 10.1128/mSphere.00261-18.

Leslie JL, Jenior ML, Schloss PD, & Young VB. (2018). The role of adaptive immunity in intra-strain exclusion of Clostridium difficile in mice. In preparation.

Leslie JL, Jenior ML, Schloss PD, & Young VB. (2018). Nutrient-based competition drives drives in vivo colonization resistance between strains of the bacterial pathogen Clostridium difficile. In preparation.

Jenior ML, Leslie JL, Young VB, & Schloss PD. (2017). Clostridium difficile colonizes alternative nutrient niches across susceptible murine gut microbiomes. mSystems. 2 (4); e00063-17.

Schloss PD, Westcott SL, Jenior ML, & Highlander SK. (2016). Sequencing 16S rRNA gene fragments using the PacBio SMRT DNA sequencing system. PeerJ. 4:e1869.

Baxter NT, Wan J J, Schubert AM, Jenior ML, Myers P, & Schloss PD. (2015). Intra- and Interindividual variations Mask Interspecies Variation in the Microbiota of Sympatric Peromyscus populations. AEM. 81(1); 396–404.

Professional Societies

Michigan Life sciences Engineering Advising and Development, 2016 - 2017

Anaerobe Society of the Americas, 2014 - present

American Society of Microbiology, 2013 - present

Cellular Biotechnology Training Program, 2012 - 2017

Oral & Poster Presentations

  • 5th Conference on Constraint-Based Reconstruction and Analysis - Seattle, WA October 14-16, 2018
  • Anaerobe Society of the Americas - Nashville, TN July 11-14, 2016
  • Michigan Meeting on Microbial Communities - Ann Arbor, MI May 16-18, 2016
  • Biannual Cellular Biotechnology Symposium - Ann Arbor, MI April 14, 2016
  • American Society for Microbiology Michigan Branch Meeting - Ann Arbor, MI October 24, 2015
  • University of Michigan Microbiome Symposium - Ann Arbor, MI September 10, 2015
  • Cellular Biotechnology Training Program Symposium - Ann Arbor, MI April 13, 2015
  • 5th ASM Conference on Beneficial Microbes - Washington D.C. September 27-30, 2014
  • Anaerobe Society, Young Investigator’s Competition - Chicago, IL June 29-July 1, 2014
  • NIH Enterics Research Investigational Network Meeting - Traverse City, MI June 2-4, 2013

Grants & Awards

  • Journal cover article, mSystems July 2017 Jenior et. al. (2017) mSystems. DOI: 10.1128/mSystems.00063-17.
  • Finalist & 3rd place, Young Investigator’s Poster Competition July 2016 Anaerobe Society of the Americas Conference
  • Rackham Travel Grant, University of Michigan July 2016
  • Beneficial Microbes 2014 Travel Grant, ASM August 2014
  • Rackham Travel Grant, University of Michigan August 2014
  • Finalist & Honorable Mention, Young Investigator’s Poster Competition June 2014 Anaerobe Society of the Americas Conference
  • Rackham Candidate Fellowship, University of Michigan April 2014
  • Cellular Biotechnology Training Grant, University of Michigan September 2012
  • Rackham Pre-Candidate Fellowship, University of Michigan December 2012
  • Kelton Scott MacMurray Memorial Scholarship, Hiram College May 2011
  • Graduated Cum Laude, Hiram College May 2011
  • Louis DiSalvo Memorial Research Assistantship in Microbiology June 2009

Service

  • Genesee County Health Department Community Lead Screening Event, Flint MI - March 19th, 2016
  • Microbiology and Immunology Student Invited Speaker Coordinator - Dr. Jo Handelsman, 2015 - 2016
  • Microbiology and Immunology Student Event Planner, September 2015 – present
  • Pioneer High School Science Fair Judge - Biology and Computer Science - 2014, 2016
  • Graduate Student Council Representative member, March 2014 – 2016
  • PIBS recruitment weekend organizer and guide, January 2012 - 2016

References

Jason Papin, Ph.D. Professor of Biomedical Engineering University of Virginia Email: papin@virginia.edu

Patrick Schloss Ph.D. Professor of Microbiology & Immunology University of Michigan Email: pschloss@umich.edu

Gregory Dick Ph.D. Associate Professor of Earth and Environmental Sciences University of Michigan Email: gdick@umich.edu