Matthew Jenior PhD

Training

  • Postdoctoral Training - Biomedical Engineering, University of Virginia, August 2017 - present
  • Ph.D. - Microbiology & Immunology, University of Michigan, July 2011 - July 2017
  • B.A. - Biology, Hiram College - graduated Cum Laude, August 2007 - May 2011

Research & Experience

Postdoctoral Research Associate with Dr. Jason Papin, University of Virginia, August 2017 - present

  • My postdoctoral research centers on implementing metabolic network reconstruction techniques, with integration of high-throughput metatranscriptomic and metabolomic data in order to engineer probiotic bacterial consortia against Clostridioides difficile infection.

Ph.D. Candidate with Dr. Patrick Schloss, University of Michigan, April 2012 – July 2017

  • My dissertation research investigated the role of nutrient niche exclusion by the gut microbiome in colonization resistance to Clostridium difficile infection. I accomplished this through the use of metagenomic-enabled metatranscriptomics to identify how community-level metabolism shifted in response to antibiotic treatment and pathogen colonization.

Research Internship, Janssen Pharmaceuticals, June 2011 – August 2011

  • Immunological Research Department – Used machine learning algorithms to predict Crohn’s disease patient response to drug therapy combining both microbiome and host epithelial microarray data.

Research Internship, Kent State University, June 2010 – August 2010

  • Laboratory of Dr. Helen Piontkivska – Constructed a relational database of HIV-1 epitope co-occurrence and immunodominance across subtypes of the virus to uncover frequently occurring patterns for potential vaccine design.

Research Assistantship, Hiram College, February 2009 – December 2010

  • Laboratory of Dr. Bradley Goodner – Worked to elucidate functional differences between five putative copies of glutamine synthetase in Agrobacterium tumefaciens using forward genetic screens.

Publications

Jenior ML, Dickenson ME, & Papin JA. (2021). Genome-scale metabolic modeling reveals increased reliance on valine catabolism in clinical isolates of Klebsiella pneumoniae. Under Review. BioRxiv. DOI: 10.1101/2021.09.08.459555

Jenior ML+ & Papin JA+. (2021). Computational approaches to understanding Clostridioides difficile metabolism and virulence. Current Opinion in Microbiology. Under Review.

Moutinho TJ, Neubert BC, Jenior ML, & Papin JA. (2021). Quantifying cumulative phenotypic and genomic evidence for the presence of biochemical functions in bacteria. Under Review. BioRxiv. DOI: 10.1101/2021.08.13.456222

Smith AB, Jenior ML, Orlaith K, Hart JL, Specker J, Rangel PC, Nicholson MR, Ren Y, Laut C, Papin J, Bushman FD, Erlichman J, Baldassano R, Prentice BM, Skaar EP, & Zackular JP. (2021). Microbial cooperation enhances Clostridioides difficile pathogenesis. Under Review.

Jenior ML, Leslie JL, Powers DA, Garrett EM, Dickenson ME, Walker KA, Petri WA Jr., Tamayo R, & Papin JA. (2021). Novel drivers of virulence in Clostridioides difficile identified via context-specific metabolic network analysis. mSystems. https://journals.asm.org/doi/10.1128/mSystems.00919-21

Dunphy LJ, Kollinga GL, Jenior ML, Carroll J, Attai AE, Farnoud F, Mathers AJ, Hughes MA, & Papin JA. (2021). Multidimensional Clinical Surveillance of Pseudomonas aeruginosa Reveals Complex Relationships between Isolate Source, Morphology, and Antimicrobial Resistance. mSphere. https://journals.asm.org/doi/10.1128/mSphere.00393-21

Leslie JL, Jenior ML, Vendrov KC, Standke AK, Barron MR, TJ O’Brien, Unverdorben L, Thaprawat P, Bergin IL, Schloss PD, & Young VB. (2021). Protection from Lethal Clostridioides difficile Infection via Intraspecies Competition for Cogerminant. Mbio 12 (2), e00522-21

Leslie JL, Weddle E, Yum LK, Lin Y, Jenior ML, Lee B, Ma JZ, Kirkpatrick BD, Nayak U, Platts-Mills JA, Agaisse HF, Haque R, & Petri Jr. WA. (2020). Lewis Blood Group Antigens are Associated with Altered Susceptibility to Shigellosis. Clinical Infectious Diseases 1409

Jenior ML, Papin JA. (2020). Clostridioides difficile: Sometimes it pays to be difficult. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2020.08.010

Dougherty BV, Rawls KD, Kolling GL, Jenior ML, & Papin JA. (2020). Identifying biomarkers of cardiotoxicity using a metabolic model constrained by omics data. In Preparation.

Hagan AK, Lesniak NA, Balunas MJ, Bishop L, Close WL, Doherty MD, Elmore AG, Flynn KJ, Hannigan GD, Koumpouras CC, Jenior ML, Kozik AJ, McBride K, Rifkin SB, Stough JMA, Sovacool KL, Sze MA, Tomkovich S, Topcuoglu BD, & Schloss PD. (2020). Ten Simple Rules to increase computational skills among biologists with Code Clubs. PLOS Comp Biol. https://doi.org/10.1371/journal.pcbi.1008119

Dunphy LJ, Kolling GL, Jenior ML, Carroll GL, Attai AE, Mathers AL, Hughes MA, & Papin JA. (2020). Multidimensional surveillance of Pseudomonas aeruginosa isolates in a single healthcare system reveals novel infection patterns. In Submission.

Leslie JL, Jenior ML, Papin JA, & Petri WA Jr. (2020). Western-style diet creates context-specific, microbiome-dependent pathogenic innate responses to C. difficile infection. In Preparation.

Leslie JL, Weddle E, Yum LK, Jenior ML, Lee B, Ma JZ, Kirkpatrick BD, Platts-Mills J, Agaisse HF, Haque R, & Petri WA Jr. (2020). Lewis Blood Group Antigens are Associated with Altered Susceptibility to Shigella. In Press.

Jenior ML, Moutinho TJ, Dougherty BV, & Papin JA. (2020). Transcriptome-guided parsimonious flux analysis improves predictions with metabolic networks in complex environments. PLOS Comp Biol. https://doi.org/10.1371/journal.pcbi.1007099

Moutinho TJ, Neubert BC, Jenior ML, Carey MA, Medlock GL, Kolling GL, Papin JA. (2020). Functional Anabolic Network Analysis of Human-associated Lactobacillus Strains. In Submission.

Leslie JL, Jenior ML, Schloss PD, & Young VB. (2020). Protection from lethal Clostridioides difficile infection via intra-species competition for co-germinant. Under Review.

Leslie JL, Vendriv K, Jenior ML, & Young VB. (2019). The gut microbiota is associated with clearance of Clostridium difficile infection independent of adaptive immunity. mSphere. DOI: 10.1128/mSphereDirect.00698-18.

Jenior ML, Leslie JL, Young VB, & Schloss PD. (2018). Clostridium difficile differentially alters the structure and metabolism of distinct cecal microbiomes to promote persistent colonization during infection. mSphere. 3 (3) e00261-18; DOI: 10.1128/mSphere.00261-18.

Leslie JL, Jenior ML, Schloss PD, & Young VB. (2018). The role of adaptive immunity in intra-strain exclusion of Clostridium difficile in mice. In preparation.

Leslie JL, Jenior ML, Schloss PD, & Young VB. (2018). Nutrient-based competition drives drives in vivo colonization resistance between strains of the bacterial pathogen Clostridium difficile. In preparation.

Jenior ML, Leslie JL, Young VB, & Schloss PD. (2017). Clostridium difficile colonizes alternative nutrient niches across susceptible murine gut microbiomes. mSystems. 2 (4); e00063-17.

Schloss PD, Westcott SL, Jenior ML, & Highlander SK. (2016). Sequencing 16S rRNA gene fragments using the PacBio SMRT DNA sequencing system. PeerJ. 4:e1869.

Baxter NT, Wan J J, Schubert AM, Jenior ML, Myers P, & Schloss PD. (2015). Intra- and Interindividual variations Mask Interspecies Variation in the Microbiota of Sympatric Peromyscus populations. AEM. 81(1); 396–404.

Grants & Awards

  • Trans-University Microbiome Initiative Pilot Award UVA - April 2020
  • Editor’s Pick, mSystems - July 2017 Jenior et. al. (2017) mSystems. DOI: 10.1128/mSystems.00063-17.
  • Finalist & 3rd place, Young Investigator’s Poster Competition - July 2016 Anaerobe Society of the Americas Conference
  • Rackham Travel Grant, University of Michigan - July 2016
  • Beneficial Microbes 2014 Travel Grant, ASM - August 2014
  • Rackham Travel Grant, University of Michigan - August 2014
  • Finalist & Honorable Mention, Young Investigator’s Poster Competition - June 2014 Anaerobe Society of the Americas Conference
  • Rackham Candidate Fellowship, University of Michigan - April 2014
  • Cellular Biotechnology Training Grant, University of Michigan - September 2012
  • Rackham Pre-Candidate Fellowship, University of Michigan - December 2012
  • Kelton Scott MacMurray Memorial Scholarship, Hiram College - May 2011
  • Graduated Cum Laude, Hiram College - May 2011
  • Louis DiSalvo Memorial Research Assistantship in Microbiology - June 2009

Presentations

  • Trans-University Microbiome Initiative seminar series - Charlottesville, VA October 12, 2021
  • Society for Mathematical Biology Annual Meeting - Montreal, Canada July 22-26, 2019
  • 5th Conference on Constraint-Based Reconstruction and Analysis - Seattle, WA October 14-16, 2018
  • Anaerobe Society of the Americas - Nashville, TN July 11-14, 2016
  • Michigan Meeting on Microbial Communities - Ann Arbor, MI May 16-18, 2016
  • Biannual Cellular Biotechnology Symposium - Ann Arbor, MI April 14, 2016
  • American Society for Microbiology Michigan Branch Meeting - Ann Arbor, MI October 24, 2015
  • University of Michigan Microbiome Symposium - Ann Arbor, MI September 10, 2015
  • Cellular Biotechnology Training Program Symposium - Ann Arbor, MI April 13, 2015
  • 5th ASM Conference on Beneficial Microbes - Washington D.C. September 27-30, 2014
  • Anaerobe Society, Young Investigator’s Competition - Chicago, IL June 29-July 1, 2014
  • NIH Enterics Research Investigational Network Meeting - Traverse City, MI June 2-4, 2013

Leadership & Service

  • Taught lecture section of Microbiology 8400 (graduate-level) - April 7, 2021
  • University of Virginia Postdoctoral Association Founding Member - November 8, 2018
  • Genesee County Health Department Community Lead Screening Event, Flint MI - March 19th, 2016
  • Microbiology and Immunology Student Invited Speaker Coordinator - Dr. Jo Handelsman, 2015 - 2016
  • Microbiology and Immunology Student Event Planner, September 2015 – present
  • Pioneer High School Science Fair Judge - Biology and Computer Science - 2014, 2016
  • Graduate Student Council Representative member, March 2014 – 2016
  • PIBS recruitment weekend organizer and guide, January 2012 - 2016

Professional Societies

Society for Mathematical Biology, 2019 - present

University of Virginia Postdoctoral Association, 2018 - present

Michigan Life sciences Engineering Advising and Development, 2016 - 2017

Anaerobe Society of the Americas, 2014 - present

American Society of Microbiology, 2013 - present

Cellular Biotechnology Training Program, 2012 - 2017

References can be made available upon request.